Disease and Its Causes, William Thomas Councilman [best historical fiction books of all time .txt] 📗

It undergoes constant change, and there is constant interchange with the environment. The molecules which compose it are constantly undergoing change in their number, kind and arrangement. Atom groups as decomposition products are constantly given off from it, and in return it receives from without other atom groups with which it regenerates its substance or increases in amount. All definitions of life convey this idea of activity. Herbert Spencer says, "Life is the continuous adjustment of internal relations to external conditions." The molecules of the substances forming the living material are large, complex and unstable, and as such they constantly tend to pass from the complex to the simple, from unstable to stable equilibrium. The elementary substances which form living material are known, but it has hitherto not been found possible artificially so to combine these substances that the resulting mass will exhibit those activities which we call the phenomena of life. The distinction between living and nonliving matter is manifest only when the sum of the activities of the living matter is considered; any single phenomenon of the living may appear also in the non-living material. Probably the most distinguishing criterion of living matter is found in its individuality, which undoubtedly depends upon differences in structure, whether physical or chemical, between the different units.

Certain conditions are essential for the continued existence of living matter. It must be surrounded by a fluid or semi-fluid medium in order that there may be easy interchange with the environment. It must constantly receive from the outside a supply of energy in the form of food, and substances formed as the result of the intracellular chemical activity must be removed. In the case of many animals it seems as though the necessity of a fluid environment for living matter did not apply, for the superficial cells of the skin have no fluid around them; these cells, however, are dead, and serve merely a mechanical or protective purpose. All the living cells of the skin and all the cells beneath this have fluid around them.

Living matter occurs always in the form of small masses called "cells," which are the living units. The cells vary in form, structure and size, some being so large that they can be seen with the naked eye, while others are so small that they cannot be distinctly seen with the highest power of the microscope. The living thing or organism may be composed of a single cell or, in the case of the higher animals and plants, may be formed of great numbers of cells, those of a similar character being combined in masses to form organs such as the liver and brain.

In each cell there is a differentiated area constituting a special structure, the nucleus, which contains a peculiar material called "chromatin." The nucleus has chiefly to do with the multiplication of the cell and contains the factors which determine heredity. The mass outside of the nucleus is termed "cytoplasm," and this may be homogeneous in appearance or may contain granules. On the outside there is a more or less definite cell membrane. It is generally believed that the cell material has a semi-fluid or gelatinous consistency and is contained within an intracellular meshwork. It is an extraordinarily complex mass, whether regarded from a chemical or physical point of view. (Fig. 1.)

Fig. 1—Diagram Of Cell. 1. Cell membrane. 2. Cell substance or cytoplasm. 3. Nucleus. 4. Nuclear membrane. 5. Nucleolus.

Fig. 1—Diagram Of Cell. 1. Cell membrane. 2. Cell substance or cytoplasm. 3. Nucleus. 4. Nuclear membrane. 5. Nucleolus.

A simple conception of health and disease can be arrived at by the study of these conditions in a unicellular animal directly under a microscope, the animal being placed on a glass slide. For this purpose a small organism called "Amoeba" (Fig. 2), which is commonly present in freshwater ponds, may be used. This appears as a small mass, seemingly of gelatinous consistency with a clear outline, the exterior part homogeneous, the interior granular. The nucleus, which is seen with difficulty, appears as a small vesicle in the interior. Many amoebæ show also in the interior a small clear space, the contractile vesicle which alternately contracts and expands, through which action the movement of the intracellular fluid is facilitated and waste products removed. The interior granules often change their position, showing that there is motion within the mass. The amoeba slowly moves along the surface of the glass by the extension of blunt processes formed from the clear outer portion which adhere to the surface and into which the interior granular mass flows. This movement does not take place by chance, but in definite directions, and may be influenced. The amoeba will move towards certain substances which may be placed in the fluid around it and away from others. In the water in which the amoebæ live there are usually other organisms, particularly bacteria, on which they feed. When such a bacterium comes in contact with an amoeba, it is taken into its body by becoming enclosed in processes which the amoeba sends out. The enclosed organism then lies in a small clear space in the amoeba, surrounded by fluid which has been shown to differ in its chemical reaction from the general fluid of the interior. This clear space, which may form at any point in the body, corresponds to a stomach in a higher animal and the fluid within it to the digestive fluid or gastric juice. After a time the enclosed organism disappears, it has undergone solution and is assimilated; that is, the substances of which its body was composed have been broken up, the molecules rearranged, and a part has been converted into the substance of the amoeba. If minute insoluble substances, such as particles of carmine, are placed in the water, these may also be taken up by the amoeba; but they undergo no change, and after a time they are cast out. Under the microscope only the gross vital phenomena, motion of the mass, motion within the mass, the reception and disintegration of food particles, and the discharge of inert substances can be observed. The varied and active chemical changes which are taking place cannot be observed.

Fig. 2.—Amoeba. 1. Nucleus. 2. Contractile vesicle. 3. Nutritive vacuole containing a bacillus.

Fig. 2.—Amoeba. 1. Nucleus. 2. Contractile vesicle. 3. Nutritive vacuole containing a bacillus.

Up to the present it has been assumed that the environment of the amoeba is that to which it has become adapted and which is favorable to its existence. Under these conditions its structure conforms to the type of the species, as do also the phenomena which it exhibits, and it can assimilate food, grow and multiply. If, during the observation, a small crystal of salt be placed in the fluid, changes almost instantly take place. Motion ceases, the amoebæ appear to shrink into smaller compass, and they become more granular and opaque. If they remain a sufficiently long time in this fluid, they do not regain their usual condition when placed again in fresh water. None of the phenomena which characterized the living amoebæ appear: we say they are dead. After a time they begin to disintegrate, and the bacteria contained in the water and on which the amoebæ fed now invade their tissue and assist in the disintegration. By varying the duration of the exposure to the salt water or the amount of salt added, a point can be reached where some, but not all, of the amoebæ are destroyed. Whether few or many survive depends upon the degree of injury produced. Much the same phenomena can be produced by gradually heating the water in which the amoebæ are contained. It is even possible gradually to accustom such small organisms to an environment which would destroy them if suddenly subjected to it, but in the process of adaptation many individuals will have perished.

It is evident from such an experiment that when a living organism is subject to an environment to which it has not become adapted and which is unfavorable, such alterations in its structure may be produced that it is incapable of living even when it is again returned to the conditions natural to it. Such alterations of structure or injuries are called the lesions of disease. We have seen that in certain individuals the injury was sufficient to inhibit for a time only the usual manifestations of life; these returned when the organism was removed from the unfavorable conditions, and with this or preceding it the organisms, if visibly altered, regained the usual form and structure. We may regard this as disease and recovery. In the disease there is both the injury or lesion and the derangement of vital activity dependent upon this. The cause of the disease acted on the organism from without, it was external to it. Whether the injurious external conditions act as in this case by a change in the surrounding osmotic pressure, or by the destruction of ferments within the cell, or by the introduction into the cell of substances which form stable chemical union with certain of its constituents, and thus prevent chemical processes taking place which are necessary for life, the result is the same.

The experiments with the amoebæ show also two of the most striking characteristics of living matter. 1. It is adaptable. Under the influence of unusual conditions, alterations in structure and possibly in substance, may take place, in consequence of which the organisms under such external conditions may still exhibit the usual phenomena. The organism cannot adapt itself to such changes without undergoing change in structure, although there may be no evidence of such changes visible. This alteration of structure does not constitute a disease, provided the harmonious relation of the organism with the environment be not impaired. An individual without a liver should not be regarded as diseased, provided there can be such an internal adjustment that all of the vital phenomena could go on in the usual manner without the aid of this useful and frequently maligned organ. 2. It is individual. In the varying degrees of exposure to unfavorable conditions of a more serious nature some, but not all, of the organisms are destroyed; in the slight exposure, few; in the longer, many. Unfavorable conditions which will destroy all individuals of a species exposed to them must be extremely rare.1 There is no such individuality in non-living things. In a mass of sugar grains each grain shows just the same characteristics and reacts in exactly the same way as all the other grains of the mass. Individuality, however expressed, is due to structural variation. It is almost impossible to conceive in the enormous complexity of living things that any two individuals, whether they be single cells or whether they be formed of cell masses, can be exactly the same. It is not necessary to assume in such individual differences that there be any variation in the amount and character of the component elements, but the individuality may be due to differences in the atomic or molecular arrangements. There are two forms of tartaric-acid crystals of precisely the same chemical formula, one of which reflects polarized light to the left, and the other to the right. All the left-sided crystals and all the right-sided are, however, precisely the same. The number of possible variations in the chemical structure of a substance so complex as is protoplasm is inconceivable.

In no way is the individuality of living matter more strongly expressed than in the resistance to disease. The variation in the degree of resistance to an unfavorable environment is seen in every tale of shipwreck and exposure. In the most extensive epidemics certain individuals are spared; but here care must be exercised in interpreting the immunity, for there must be differences in the degree of exposure to the cause of the epidemic. It would not do to interpret the immunity to bullets in battle as due to any individual peculiarity, save possibly a tendency