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into your bloodstream and started to replicate, just like it did in Kristen. We’re seeing a process known as ‘engraftment.’ These special cells have learned to mimic any cell they come near. They become the tissue that those cells comprise and begin replacing the healthy tissue with new. In Kristen’s case, we think it’s now entered her brain and it seems to be supplanting her memory tissue with blanks. The same side effect could eventually evolve in you.”

That doesn’t begin to describe the real horror, Bartlett thought. It’s too impossible to imagine.

“The only thing left is to find some way to cause your body to reject the enzyme,” Van de Vliet said. “I’m optimistic that we might be able to grow some telomerase antibodies in another patient with your blood type, then culture enough of them to stop the Syndrome in its tracks. It’s worth a try. Frankly, I can’t think of anything else. But your blood type is AB, which is extremely rare. Also, the problem is that we’d possibly be putting that other person at severe risk too.”

“Let’s go back up to the lab,” Bartlett said. “That idea of yours-Hampton thinks he’s got somebody. A woman, in her late thirties.” He put his hand on Van de Vliet’s shoulder. “We’re going to get her on board however we have to.”

Chapter 3

Sunday, April 5

8:49 A.M.

Stone Aimes was staring at the e-mail on the screen of his Compaq Armada and feeling an intense urge to put his fist through its twisted spiral crystals. What do you do when you’ve come up with an idea that could possibly save thousands of lives using simple Web-based technology and then the piece gets spiked by your newspaper’s owners at the very last minute because it exposes some important New York hospitals to unpleasant (but constructive) scrutiny?

What it makes you want to do is tell everybody down on the third floor to stuff it and walk out and finish your book-undistracted by corporate ass-covering BS… or, unfortunately, by a paycheck.

Around him the newsroom of the New York Sentinel, a weekly newspaper positioned editorially somewhere between the late, lamented New York Observer and the Village Voice, was in final Sunday countdown, with the Monday edition about to be put to bed. The technology was state of the art, and the room flickered with computer screens, blue pages that gave the tan walls an eerie cast. Composition, spell-checking, everything, was done by thinking machines, and the reporters, thirteen on this floor, were mostly in their late twenties and early thirties and universally underpaid.

The early morning room was bustling, though it felt to Stone like the end of time. Nobody was paying any attention to him but that was normal: everybody was doing their own thing. Besides, nobody else realized he’d just had a major piece killed at the last minute. Now he felt as though he were frozen in place: in this room, in this job, in this life.

The book he had almost finished was going to change a lot of things. It would be the first major explication of stem cell technology for general readers. Stem cells were going to revolutionize everything we knew about medicine and the research was going further than anyone could have dreamed. The possibility of reversing organ degeneration, even extending life, was hovering right out there, just at humankind’s fingertips. It cried out for a major book.

He had read everything that had made its way into the medical journals, but the study that was furthest along was privately funded and now cloaked in secrecy. It was at the Gerex Corporation, whose head researcher was a Dutch genius named Karl Van de Vliet. The company had been bankrolled by the medical mogul Winston Bartlett after Van de Vliet lost his funding at Stanford.

Winston Bartlett, of all people… but that was another story.

Thirteen months earlier, the Gerex Corporation had trolled for volunteers on the National Institutes of Health Web site, referring to a pending “special study.” The notice suggested the study might be using stem cell technology in some fashion. If that study was what Stone Aimes thought it was, it would be the first to use stem cells in stage-three clinical trials. Nobody else was even close.

Karl Van de Vliet was the ball game. Unfortunately, however, his study was being held in an atmosphere of military-like secrecy. Why? Even the identities of the participants in the trials were like a state secret. Since Winston Bartlett owned Gerex, it surely had been ordered by him. You had to wonder what that was all about.

Whatever the reason, Stone Aimes knew that in order to finish his book with the latest information he had to get to Van de Vliet. But Bartlett had forbidden any interviews, and Gerex’s clinic, called the Dorian Institute, was off-limits to the public and reportedly guarded with serious security.

But, he thought, perhaps he had just come up with an idea of how to get around that….

He stared a moment longer at the dim reflection coming back at him from the antiglare screen, which now informed him that his cover feature had been chopped. Truthfully, it was happening more and more; this was the third time in eight months that a major muckraking piece had been axed. Also, as he stared at it, the reflection told him he wasn’t getting any younger. The hairline was no longer where it had been in his college photos-it was up about half an inch-and the blue eyes were sadder, the lines under them deeper.

Still, the tousled brown hair was thick enough, the brow mostly wrinkle-free, and he still had hope. He wasn’t exactly young anymore, but neither was he “getting on.” The “Willy Loman” years remained safely at bay. He was thirty-nine and divorced, with an ex-wife, Joyce, who had departed to be a garden designer in northern California, taking with her their daughter, Amy, on whom he doted. He had a one-bedroom, rent-controlled apartment in the East Nineties, on the top floor of a fashionable brownstone. He was socially unattached, as the expression goes, but he was so compulsive about finishing the book that he spent weekends hunched over his IBM Aptiva, nursing a six-pack of Brooklyn Lager and writing deathless prose. The truth was he was lonely, but he didn’t allow himself to think about it.

He’d always vowed he’d amount to something by forty. And now it was as much for Amy as for himself. She lived with his ex-wife near El Cerrito, California, and she meant the world to him. The mortifying part was, he was a week behind with this month’s support check. And he knew Joyce needed the money. It made him feel like a callous deadbeat dad when the real culprit was an unlucky confluence of inescapable bills. He’d make it up next week, but he’d sworn he would never let this happen.

That was why he had a larger game plan. Get out of this frigging day job and finish the book. The time for that plan to kick in was approaching at warp speed. This last insult was surely God’s not-so-subtle way of informing him that his future was in the freelance world. Every day out there would be a gamble, but he could write anything he damn well pleased.

There was a parable set down by the ancient Taoist philosopher Lao Tzu that Stone Aimes reflected on more and more these days. It was the story of two oxen: One was a ceremonial sacrificial ox who, for the year before he meets the axe, was feted with garlands of lotus flowers and plied with ox goodies. The other was a wild ox who had to scrounge in the forest for every scrap. But, the story went, on the day the ax was to drop, what wouldn’t that ceremonial ox give to change places with that haggard struggling, underfed wild ox?

That’s the one he empathized with. The one who was out there, half starved but free.

The Sentinel was an iron rice bowl that normally never let anybody go except for grossest incompetence or flagrant alcoholism. On the other hand getting ahead was all about office politics, kissing the managing editor’s hindquarters, and copying him on every memo to anybody to make sure nobody else took credit for something you thought of.

On the plus side, he knew he was a hell of a medical journalist. There was such a gap between medical research and what most people knew, the field cried out for a Stephen Hawking of health, a medical Carl Sagan. The way he saw it, there was room at the top and he was ready for a major career breakthrough. He had done premed at Columbia before switching to journalism, and these days he read the Journal of the American Medical Association from cover to cover, every issue, along with skimming the many other journals now on the web.

The piece that just got cut was intended to show the world that investigative journalism was alive and well and trying to make a difference. He’d documented that hospital mistakes were actually the eighth leading cause of death in the United States. The Institute of Medicine estimated that medical errors caused between fifty and a hundred thousand deaths a year-rivaling the number from auto accidents or AIDS. (He’d gotten enough data to be able to quantify how many of those deaths were in leading New York hospitals.) Yet there was no federal law requiring hospitals to report mistakes that caused serious injury or death to patients.

The reason seemed to be that the medical lobby—he’d named names-had successfully turned back all attempts by Congress to pass such a law, even though it was a formal recommendation by the Institute of Medicine. The problem was, once you admitted you screwed up, you could get sued.

So there was no formal accountability.

But (and here was the constructive part) if patients’ medical records were put on the Web-everything, even their medications-it could make a big dent in the all-too-frequent hospital medication foul-ups. That alone could cut accidental hospital deaths in half.

He’d pitched Jay Grimes, the managing editor, to let him do a five-thousand-word piece for the Sentinel. Jay had agreed and even promised him the front page. Jay liked him, but since all the real decisions were made by the owners, not-so-affectionately known as the Family, there wasn’t much Jay could do to protect his people. Stone now realized that more than ever.

The e-mail on his Compaq’s screen was from Jane Tully, who handled legal affairs for the paper. Apparently, Jay didn’t have the balls to be the hatchet man, so he’d given the job to Jane, who could throw in a little legal mumbo jumbo for good measure. And she hadn’t even had the courtesy to pick up the phone to do the deed. Instead, she’d sent a frigging e-mail: See attached. Corporate says legal implications convey unacceptable risk. Consider an op-ed piece. That way the liability will be all yours. Love and kisses.

And of course, by “Corporate,” she meant the Family (or, more likely, their running-dog attorneys down on Nassau Street).

It was really too bad about Jane. She was a young-looking thirty-six and had her own legal practice with a large law firm in midtown, but she always dropped by before her Sunday brunch to answer any legal questions that might be pending before the Sentinel was put to bed. Stone knew pretty well how her mind worked. He should. Jane Tully was his former, very former, significant other.

They d lived together for a year and a half on First Avenue in the East Sixties. But she was type A (tailored Armani suits and always on time) and he was a type B (elbow patches and home-cooked pasta). The denouement had been seismic and

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